Shanaz Dairkee, Ph.D.
Email: DairkeS@cpmcri.org
Introduction
I am a senior scientist and principal investigator at California Pacific Medical Center Research Institute since 1994. My research program is focused on designing new methods and approaches for studying cellular and molecular changes during the early stages of breast cancer progression. This research aims to improve tumor targeting and prevention through a better understanding of basic tumor biology.
Primarily, through the National Institutes of Health (NIH) grants, we have made an important breakthrough in the development of cell culture models from patient tissue which can assist in identifying characteristics of individual patient tumors that are specifically related to the malignant process.
Many aspects of my research involve cooperative efforts with other scientific groups. Together with the University of California, San Francisco, in a National Cancer Institute (NCI) awarded Specialized Program of Research Excellence (SPORE), I am participating as Project Head on a highly translational study of molecular markers which define women at high risk for breast cancer.
In addition, I am Cell Biology Core Leader on a multidisciplinary NCI-awarded program project on breast cancer prognosis. A more recent NIH award has given me the opportunity to join a multi-institutional consortium of molecular biologists towards the development of methods to study gene expression in breast tumors.
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Chemical, bisphenol A, in Plastic Changes Breast Cell Gene Activity
Dairkee SH, Seok J, Champion S, Sayeed A, Mindrinos M, Xiao W, Davis RW, Goodson WH. Bisphenol A induces a profile of tumor aggressiveness in high-risk cells from breast cancer patients.
Cancer Res. 2008 Apr 1;68(7):2076-80.
The following are a few links this study has been mentioned. There are over 300 news venues in regards to this study.
Toronto Globe and Mail
Consumer Affairs
US News and World Report
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Publications
Click to see a list of publications by Sharon Dairkee from PubMed.
1: Dairkee SH, Seok J, Champion S, Sayeed A, Mindrinos M, Xiao W, Davis RW, Goodson WH. Bisphenol A induces a profile of tumor aggressiveness in high-risk cells from breast cancer patients.
Cancer Res. 2008 Apr 1;68(7):2076-80.
2: Yau C, Fedele V, Roydasgupta R, Fridlyand J, Hubbard A, Gray JW, Chew K, Dairkee SH, Moore DH, Schittulli F, Tommasi S, Paradiso A, Albertson DG, Benz CC. Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers.
Breast Cancer Res. 2007;9(5):R59.
3: Dairkee SH, Nicolau M, Sayeed A, Champion S, Ji Y, Moore DH, Yong B, Meng Z, Jeffrey SS. Oxidative stress pathways highlighted in tumor cell immortalization: association with breast cancer outcome.
Oncogene. 2007 Sep 20;26(43):6269-79. Epub 2007 Apr 30.
4: Zhou Y, Yau C, Gray JW, Chew K, Dairkee SH, Moore DH, Eppenberger U, Eppenberger-Castori S, Benz CC. Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer.
BMC Cancer. 2007 Apr 3;7:59.
5: Chin K, DeVries S, Fridlyand J, Spellman PT, Roydasgupta R, Kuo WL, Lapuk A, Neve RM, Qian Z, Ryder T, Chen F, Feiler H, Tokuyasu T, Kingsley C, Dairkee S, Meng Z, Chew K, Pinkel D, Jain A, Ljung BM, Esserman L, Albertson DG, Waldman FM,
Gray JW. Genomic and transcriptional aberrations linked to breast cancer pathophysiologies.
Cancer Cell. 2006 Dec;10(6):529-41.
6: Fridlyand J, Snijders AM, Ylstra B, Li H, Olshen A, Segraves R, Dairkee S, Tokuyasu T, Ljung BM, Jain AN, McLennan J, Ziegler J, Chin K, Devries S, Feiler H, Gray JW, Waldman F, Pinkel D, Albertson DG. Breast tumor copy number aberration phenotypes and genomic instability.
BMC Cancer. 2006 Apr 18;6:96.
7: Shoemaker M, Hamilton B, Dairkee SH, Cohen I, Campbell MJ. In vitro anticancer activity of twelve Chinese medicinal herbs.
Phytother Res. 2005 Jul;19(7):649-51.
8: Meng ZH, Ben Y, Li Z, Chew K, Ljung BM, Lagios MD, Dairkee SH. Aberrations of breast cancer susceptibility genes occur early in sporadic breast tumors and in acquisition of breast epithelial immortalization.
Genes Chromosomes Cancer. 2004 Nov;41(3):214-22.
9: Dairkee SH, Ji Y, Ben Y, Moore DH, Meng Z, Jeffrey SS.
A molecular 'signature' of primary breast cancer cultures; patterns resembling tumor tissue.
BMC Genomics. 2004 Jul 19;5(1):47.
10: Korkola JE, DeVries S, Fridlyand J, Hwang ES, Estep AL, Chen YY, Chew KL, Dairkee SH, Jensen RM, Waldman FM.
Differentiation of lobular versus ductal breast carcinomas by expression microarray analysis.
Cancer Res. 2003 Nov 1;63(21):7167-75.
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